Article: The race to map the human body
This article from Nature discusses how, among other things, virtual reality is being used to get a better understanding of cancer cells, how various cells in the body act when not in isolation, etc. A fairly short but interesting read.
The first time molecular biologist Greg Hannon flew through a tumour, he was astonished — and inspired. Using a virtual-reality model, Hannon and his colleagues at the University of Cambridge, UK, flew in and out of blood vessels, took stock of infiltrating immune cells and hatched an idea for an unprecedented tumour atlas.
“Holy crap!” he recalls thinking. “This is going to be just amazing.”
Over the past few years, researchers have flocked to techniques that allow them to sequence the full complement of RNAs — tens of thousands of them — in individual cells. These RNAs can reveal which genes are expressed, and provide clues as to a cell’s unique function within an organ or tumour.
But sequencing methods typically require that the cells first be plucked from the tissue in which they live. That destroys valuable information about where the cells were and what neighbours they interacted with — information that could hold new clues to a cell’s function and how it can go awry in diseased tissue.
“There is a lot of excitement and promise with single-cell sequencing technologies,” says Nicola Crosetto, a molecular biologist at the Karolinska Institute in Stockholm. “But when we think of cancer and complex physiological tissues, we need to be able to put that information into spatial context.”
What are your thoughts?